Endocrine Abstracts

Context: Tissue-specific dicer1 knockout female mice display severe and irreversible damage to the Fallopian tubes that eventually leads to disruption of tubal transport of the gametes and the early embryo. The impact of Dicer1 on the function of human Fallopian tubes remains to be clarified.Objective: To determine how the expression of tubal Dicer1 is regulated in women during the ovulatory process and in the mid-secretory phase. Furthermore, the...

Polycystic ovary syndrome (PCOS) is a significant risk factor for the development and progression of type I endometrial cancer (EC). Currently, it is not known whether metformin has a direct effect on the endometria and further regulates glycolysis and mitochondrial function in PCOS patients with endometrial hyperplasia and carcinoma. Here we show that endometria from PCOS patients with endometrial hyperplasia and carcinoma have a distinct protein expression pattern of glycoly...

Introduction and aimGraves’ disease which is the most common cause of hyperthyroidism is an autoimmune disease presenting with goitre, orbitopathy and dermopathy. The disease is caused by stimulant type TSH receptor antibodies (TRAB). TSH receptor (TSHR) has been shown in different tissues other than thyroid. Testis is one of the extrathyroidal tissues with TSHR. The aim of this study was to investigate relationship between TRAB and inhibin-B, whic...

Insulinoma is generally a rare benign tumor of the pancreas islet cell. The typical clinical symptom of insulinoma are repetitive hypoglycemia attacks. Insulinoma with coexisting diabetes is extremely rare condition, We aim to present a case with insulinoma conmomittant with type 2 diabetes mellitus.Case report: A 65-year-old woman diagnosed with type 2 diabetes mellitus was admitted by our internal medicine clinic. She complained from perspiration and t...

Accumulating clinical data suggest that women with polycystic ovary syndrome (PCOS) are at high risk for nonalcoholic fatty liver disease (NAFLD). However, it is not clear whether hyperinsulinemia and hyperandrogenism act concomitantly or independently to induce hepatic steatosis and inflammation, and the molecular mechanisms behind the interactions between insulin resistance and hyperandrogenism in the female liver remain largely unexplored. To achieve hyperinsulinemia, insul...

Peripheral insulin resistance and hyperandrogenism are the primary features of polycystic ovary syndrome (PCOS). However, how insulin resistance and hyperandrogenism affect uterine function and contribute to the pathogenesis of PCOS are open questions. Rodent models of insulin and human chorionic gonadotropin (hCG) treatment have provided systems in which to study ovarian insulin resistance, ovarian stromal hyperplasia, follicular cyst formation, and impaired mitochondrial fun...

Familial hypocalciuric hypercalcemia is an inherited disease caused by inactivating heterozygous mutations in the gene encoding calcium-sensitive receptors, that affects calcium metabolism and generally follows a benign course. It must be also considered in the differential diagnosis of hyperparathyroidism. Six patients presenting to our internal diseases clinic between January, 2010, and June, 2015, were evaluated in terms of clinical and biochemical parameters. The youngest ...

Objective: Agouti related peptide (AgRP), the endogenous antagonist of the melanocortin 3 and 4 receptors, is expressed at high levels in the arcuate nucleus of the hypothalamus. Some studies have demonstrated that intracerebroventricular AgRP administration increases plasma LH, FSH, testosterone levels. It also increases hypothalamic LHRH release in vitro, an effect that can be prevented by addition of melanocyte stimulating hormone. These findings suggest that AgRP ma...

Introduction: The purpose of this study was to evaluate the relation between menopausal women and the thiol/disulphide balance, used as a marker of oxidative stress, by measuring that exchange using a novel technique.Methods: Fourty five postmenopausal subject and 39 healthy participant were included in the study.Results: We found that in postmenopausal group, disulphide (P=0.04), disulphide/native thiol (P=0.004)...

Background: Carbohydrate-restricted diets in type 1 diabetes mellitus (T1DM) are highly controversial. A commonly held concern is that a low carbohydrate diet may more readily result in conversion to diabetic ketoacidosis – one of the most severe complications of poorly managed T1DM. Of note, there is no clear evidence for this phenomenon. We evaluated metabolic profiles in patients with T1DM who had self-selected carbohydrate-restricted diets.<p clas...